Important Safety Information: MOTS-C
What is MOTS-C?
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide that plays a role in regulating metabolism, insulin sensitivity, and cellular adaptation to stress. It is currently under investigation in research settings for its potential applications in metabolic disorders, aging, and mitochondrial function.
Warnings and Precautions
- Research Use Only
MOTS-C is an investigational peptide and has not been approved by regulatory agencies (e.g., FDA, EMA) for therapeutic use. It is available solely for research purposes. Any non-research use is experimental and may carry unknown risks. - Contraindications
- Do not use MOTS-C if you have a known allergy or hypersensitivity to it or any of its components.
- Avoid use during pregnancy, breastfeeding, or if planning to conceive, as the safety of MOTS-C for fetal or maternal health is not established.
- Individuals with active cancer or a history of cancer should not use MOTS-C due to its potential effects on cellular metabolism.
- Potential Side Effects
While research on MOTS-C is ongoing, potential side effects reported in studies include:- Localized injection site reactions, such as redness, swelling, or pain.
- Mild nausea, headache, or dizziness.
- Temporary fatigue or muscle discomfort.
- Allergic reactions, including rash or itching.
- Precautions for Specific Conditions
- Metabolic Disorders: Patients with diabetes or other metabolic disorders should use MOTS-C cautiously, as it may affect insulin sensitivity and glucose metabolism.
- Mitochondrial Disorders: Use with caution if you have existing mitochondrial dysfunction, as the effects of MOTS-C on such conditions are not fully understood.
Drug Interactions
- MOTS-C may interact with medications that affect metabolism, including insulin, glucose-lowering drugs, or mitochondrial-targeting therapies.
- Inform your healthcare provider of all medications, supplements, or therapies you are using to avoid potential interactions.
Usage Instructions
- Administration
- MOTS-C is typically administered via subcutaneous or intramuscular injection in research settings.
- Use sterile techniques to minimize the risk of infection.
- Dosage
- Dosages vary depending on research protocols. There is no standardized therapeutic dose. Follow instructions from your research supervisor or healthcare provider.
- Monitoring
- Regular monitoring of metabolic and mitochondrial function is recommended during MOTS-C use to evaluate safety and effectiveness.
Storage and Handling
- Store MOTS-C in a refrigerator at 2–8°C (36–46°F).
- Protect from light and moisture.
- Reconstituted solutions should be used promptly or stored according to manufacturer instructions.
- Keep out of reach of children and unauthorized individuals.
Disclaimers
- MOTS-C is not FDA-approved for human consumption or therapeutic use.
- Its long-term safety and efficacy have not been established, and it should only be used under controlled conditions in research settings.
- Off-label or unauthorized use of MOTS-C may result in significant health risks and complications.
If you experience adverse effects or have concerns about MOTS-C, consult a licensed healthcare provider immediately. For further information, contact the product distributor or manufacturer.